Anti-Hyperglycemic Effect of the Polyherbal Aqeous Extract on Glucose Tolerance Test In Streptozotocin-Induced Diabetic Rats.

ABSTRACT

Diabetes mellitus is a chronic metabolic disorder, with rapidly increasing cases worldwide posing significant concerns in both developed and developing nations. Herbal medicines have gained acceptance as alternative therapies for blood sugar control, with potent herbs like Annona muricata, Zingiber officinale, Andrographis paniculata being utilized for diabetes management.  The aim to assess the anti-diabetic activities of polyherbal extracts in streptozotocin-nicotinamide induced diabetic mice. The method used for glucose tolerance test were evaluated using standard and established method. Oral administration of polyherbal extract at doses of 50, 150, and 200 mg/kg significantly reduced blood glucose levels compared to untreated diabetic group. Specifically, the study found that the polyherbal extract at a dose of 50 mg/kg body weight led to a significant decline (p < 0.05) in blood glucose levels. The study demonstrates the efficacy of the polyherbal drug extract in reducing glucose levels over time, at 50 mg/kg of the extract. This validates its traditional use and such insights hold promise for the development of innovative treatments for metabolic disorders.