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Abstract
Edema refers to the accumulation of fluid in tissues which makes it difficult for a person because there is a decrease in movement and the quality of life gets affected. Recently, the use of several herbal extracts in controlling the symptoms of edema has been advocated. This study looks into the anti-edema activity of the N-hexane extract of the leaves of the African oil bean tree (Pentaclethra macrophylla benth). The plant has a wide application in African traditional medicine and is reported to be rich in several phytochemicals including terpenoids, flavonoids, and saponins, which have been known to reduce inflammation and vascular permeability. The present study endeavors to understand the possible mechanisms of action of the extract against edema based on published work dealing with its ability to reduce inflammation, act as an antioxidant and modulate vascular responsiveness. According to the findings, P. macrophylla leaf extract is promising for use as an anti-edema agent but its role as an anti-edematous agent should be validated clinically using humans
