ABSTRACT
Cleome rutidosperma is a plant species with medicinal properties, including antiinflammatory, widely relied upon in traditional practices. For this reason, the present research was intended to assess and, thus, ensure the safety of this plant for conventional medicinal purposes using a toxicity test study. This research sought to access the acute toxicity and haematological assessment of the methanolic, ethanolic extract and pulverized samples of Cleome rutidosperma leaves in wistar albino rats. Acute toxicity was carried out using the OECD method were the animals were grouped into 16 groups, were group one was the control group and administered normal feed and water while group 2 to 6 were administered 10mg/kg body weight of methanolic extract (MET). The animals, 100mg/kg MET extract body weight, 1600mg/kg, 2900mg/kg, 5000mg/kg of the rat respectively. While group 7-11 were treated with 10mg/kg body weight of the ethanolic extract (ETH). The animals, 100mg/kg ETH extract body weight, 1600mg/kg, 2900mg/kg, 5000mg/kg body weight of the rat respectively. Group 12-16, 10mg/kg body weight pulverized sample of rats. The animals, 100mg/kg pulverized sample body weight, 1600mg/kg, 2900mg/kg, 5000mg/kg body weight of the rat respectively. The haematological analysis was carried out and significant dosedependent changes in white blood cells (WBC), red blood cell (RBC), hemoglobin(HGB), lymphocytes, and granulocytes were shown by hematological study. Although changes in white blood cells and lymphocyte counts showed immunomodulatory action, moderate dosage of the extract notably increased RBC and HGB levels, suggesting possible erythropoietic advantages.
