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ABSTRACT
In this study, the activity of ethanol extract of Solanum nigrum (Sn) on histamine induced contraction of guinea pig trachea was investigated. Three weeks old, male guinea pigs (25 of them) were divided into five groups consisting of five pigs each were used. All animals were allowed access to standard animal feed and water. In addition animals were pre-sensitized with ovalbumin, and then exposed to 2% histamine aerosol after an overnight fast. The pre convulsion time was recorded. Animals in groups 2, 3, 4, were administered ethanol extract of Solanum nigrum leaf at the respective doses of 50, 100 and 200mg/kg body weight while animals in group 5 received 25mg/kgbw of the reference drug aminophylline. Animals were again subjected to histamine erosol after drug administration and the pre-convulsion one was again recorded. All animals were sacrificed three days after the last challenge and their trachea were excised to test the presence and reproducibility of contractile response to histamine and determination of the relaxant effect of S. nigrum. Result obtained indicates that in the absence of the extract histamine caused severe contraction in the trachea of the guinea pigs. This contraction was inhibited in the presence of the extract leading to trachea dilation by 67%.
