ABSTRACT

Diabetes mellitus, a chronic metabolic disorder, continues to pose a significant global health challenge. Traditional medicine offers a promising avenue for the discovery of novel therapeutic agents. This study begins by elucidating the biochemical basis of diabetes, emphasizing the pivotal role of insulin resistance and abnormal glucose metabolism. It then delves into the botanical origin, chemical composition, and traditional uses of Soursop extract. Notably, Soursop extract is rich in polyphenols, alkaloids, and other bioactive compounds, which are postulated to confer anti-diabetic properties.This research work was aimed at accessing the anti-diabetic potential of aqueous extract of Soursop (Annona muricata) whole fruit by evaluating the acute toxicity of Soursop (Annona muricata), investigating the normolycemic effect of Soursop on normoglygemic albino Wistar rats, investigating the antidiabetic properties of Annona muricata using animal models and evaluating its efficacy and safety as an adjunctive therapy for diabetes management using streptozotocin induced diabetes on Wistar rats. This studies demonstrate promising results, showcasing the extract's potential to lower blood glucose levels, improve insulin sensitivity, and mitigate complications associated with diabetes While preliminary findings are encouraging, rigorous scientific investigation is imperative to unlock its full therapeutic potential, offering hope for a more holistic approach to diabetes care.